Lorenzo Insigne starts his final game at the Stadio Maradona in the Napoli jersey, but Genoa know a defeat here could see them relegated.
It kicks off at 14.00 UK time (13.00 GMT), you can follow all the build-up and action as it happens from today’s four Serie A games on the LIVEBLOG.
Serie A Liveblog: Milan-Atalanta, Cagliari-Inter, Napoli-Genoa, Bologna-Sassuolo
There will be emotional scenes as home-town boy Insigne says goodbye ahead of his transfer to Toronto FC and MLS.
He’ll receive a commemorative plaque from President Aurelio De Laurentiis before kick-off and is expected to give a speech after the final whistle.
Insigne is accompanied by Dries Mertens, Hirving Lozano and Victor Osimhen, with none of these players guaranteed to be at Napoli next season.
Genoa know a defeat here could mean they are relegated to Serie B, as they have an inferior head-to-head record with Salernitana.
Their only hope if they lose is for Cagliari to draw with Inter and leave it all to the final round.
They fought back to beat Juventus 2-1 with a stoppage-time Domenico Criscito penalty, making up for the one that was saved by Sampdoria goalkeeper Emil Audero.
Nikola Maksimovic, Yayah Kallon, Stefano Sturaro, Zinho Vanheusden and Riccardo Calafiori are out of action, but Kelvin Yeboah starts upfront with support from impressive Nadiem Amiri.
Napoli: Ospina; Di Lorenzo, Rrahmani, Koulibaly, Mario Rui; Anguissa, Fabian Ruiz; Lozano, Mertens, Insigne; Osimhen
Genoa: Sirigu; Hefti, Bani, Ostigard, Criscito; Galdames, Badelj; Portanova, Amiri, Gudmundsson; Yeboah
